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Tramadol is a pain reliever. Tramadol affects chemicals and receptors in the body that are associated with pain. Tramadol is used to relieve moderate to moderately severe pain.
Tramdol is the generic of TRAMADOL.
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| Medication Description | Price Each |
| Tramadol 50mg 30 tabs | $ 48.00 |  |
| Tramadol 50mg 60 tabs | $ 67.00 | |
| Tramadol 50mg 90 tabs | $ 84.00 | |
| Tramadol 50mg 180 tabs | $ 114.00 | |
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Frequently Asked Questions
TRAMADOL
is a white, bitter, crystalline and odorless powder.
Each TRAMADOL tablet contains 50 mg of TRAMADOL
hydrochloride and is white in color.
HOW EFFECTIVE IS TRAMADOL?
TRAMADOL has been given in single
oral doses of 50, 75, 100, 150 and 200 mg to patients with pain
after surgical procedures and pain after oral surgery. In single-dose models of pain
following oral surgery, pain relief was demonstrated in some patients
at doses of 50 mg and 75 mg. A dose of 100 mg of TRAMADOL tended to
provide pain relief superior to codeine sulfate 60 mg, but it was not
effective as the combination of aspirin 650 mg with codeine phosphate
60 mg. In single-dose models of pain following surgical procedures,
150 mg provided pain relief generally equivalent to the combination of
Darvocet N-100, with a
tendency toward later peak effect. TRAMADOL has been studied in three
long-term controlled trials involving a total of 820 patients, with
530 patients receiving TRAMADOL. Patients with a variety of chronic
painful conditions were studied in double-blind trials of one to three
months duration. Mean daily doses of about 250 mg of
TRAMADOL
in divided doses were generally equivalent with five doses of
Tylenol with
Codeine #3 daily, five doses of aspirin 325 mg with codeine phosphate
30 mg daily, or two to three doses of Tylox daily.
HOW DOES TRAMADOL WORK?
TRAMADOL acts on the central nervous
system (CNS) and unlike codeine is a totally
synthetic pain relieving compound. Although TRAMADOL's biological process is not
completely understood, at least two complementary
mechanisms appear applicable: weak inhibition of reuptake of
norepinephrine and serotonin by nerves located within the (CNS)
and the binding of parent compound and its
metabolite to opioid receptors. TRAMADOL-induced pain relief is only partially reversed by
the opiate antagonist Narcan in several animal tests. TRAMADOL has
been shown to reduce reuptake of serotonin and norepinephrine in
vitro. These mechanisms may contribute independently to the
overall pain relief profile of TRAMADOL. Pain relief in humans begins
about one hour after administration and reaches maximum effect
in about two to three hours.
HOW DO I UTILIZE TRAMADOL?
For the treatment of painful symptoms
TRAMADOL 50 mg to 100 mg can be given as needed for pain relief every four to six
hours, not to exceed a maximum dose of 400 mg per day. For moderate pain
TRAMADOL 50 mg may be acceptable as the first dose, and for more severe pain, TRAMADOL 100
mg is usually more effective as the first dose.
Individualization of Dose:
Patients over 75 years old:
No more then 300 mg/day in divided doses.
Patients 65 to 75 years of age:
No dose adjustment is needed.
Patients with reduced renal fuction :
The dosing interval of TRAMADOL should be extended to twelve hours with a
maximum daily dose of 200mg/day.
Dialysis patients:
These patients can receive their usual dose on the same day as dialysis treatment.
Patients with cirrhosis:
Recommended dosage is 50 mg every 12 hours.
Patients receiving chronic Tegretol:
Doses up to 800mg/day may be required, this is up to twice the
recommended dose of TRAMADOL.
DRUG ABUSE INFORMATION:
TRAMADOL has a propensity to cause physical and psychological dependence of the
morphone-type. TRAMADOL has been associated with tolerance development, craving, and drug-seeking
behavior. Dependence and abuse cases of TRAMADOL have been reported.
TRAMADOL should not be used in patients whom are opioid-dependent.
TRAMADOL can reinitiate physical dependence in
patients that have been previously dependent or chronically using other
opioids. In patients with a tendency to abuse drugs, a history of chronically
using opiods, or drug dependence, treatment with
TRAMADOL is not recommended.
TRAMADOL AND SEIZURES:
Seizure Risk
Patients receiving TRAMADOL have reported seizures within the
recommended dosage range. Concomitant use of
TRAMADOL increases the seizure
risk in patients taking:
-Selective serotonin reuptake inhibitors (SSRI
antidepressants or anoretics -phentermine),
-Tricyclic antidepressants and other tricyclic
compounds (e.g., cyclobenzaprine, promethazine, etc.)
-Epilepsy
-Opioids.
-Neuroleptics
-MAO inhibitors
-Any drugs that reduce the seizure threshold
TRAMADOL AND DROWZINESS:
TRAMADOL may impair mental or physical abilities required for the performance
of potentially hazardous tasks such as driving a car or operating
machinery. TRAMADOL should not be taken with alcohol.
TRAMADOL should be used with caution when taking medications such as
tranquilizers, hypnotics or other pain relief medications.
TRAMADOL AND PREGNANCY:
TRAMADOL should not be used in nursing mothers or pregnant women. Safe use in
pregnancy has not been proven.
Physical dependence and post-pregnancy withdrawal symptoms in the
newborn may be seen with chronic use during pregnancy.
TRAMADOL has been shown to cross the placenta. Nonetheless, the effect of
TRAMADOL, if any, on the later growth,
development, and functional maturation of the child is unknown.
ADVERSE REACTIONS:
TRAMADOL was administered to 550 patients during the double-blind or open-label
extension periods in U.S. studies of chronic nonmalignant pain. Of these
patients, 375 were 65 years old or older. Reports the cumulative
incidence rate of adverse reactions by 7, 30 and 90 days for the most
frequent reactions (5% or more by 7 days). The most frequently reported
events were in the CNS and gastrointestinal system.
Although the reactions may be related
to TRAMADOL administration, the reported rates also include some events that may have
been due to underlying disease or concomitant medication. The overall
incidence rates of adverse experiences in these trials were similar for
TRAMADOL and the active control groups,
acetaminophen 300 mg with codeine phosphate 30 mg, and aspirin 325 mg with
codeine phosphate 30 mg.
OVERDOSAGE:
Respiratory depression and seizure are serious potential consequences of overdosage.
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